Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging
نویسندگان
چکیده
منابع مشابه
Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging
Ultrasound-sensitive (sonosensitive) liposomes for tumor targeting have been studied in order to increase the antitumor efficacy of drugs and decrease the associated severe side effects. Liposomal contrast agents having Gd(III) are known as a nano-contrast agent system for the efficient and selective delivery of contrast agents into pathological sites. The objective of this study was to prepare...
متن کاملMechanical release from paramagnetic liposomes triggered by low frequency ultrasound
Introduction Non, or minimally, invasive in vivo visualization of drug release triggered by externally-applied physical stimuli, like heating, light or ultrasound (US) is an emerging topic in molecular medicine. As far as US is concerned, most of the published investigations were performed using nanoor micro-bubbles in which the presence of the gas-filled core makes cavitation (and US detection...
متن کاملAlginate Microspheres Containing Temperature Sensitive Liposomes (TSL) for MR-Guided Embolization and Triggered Release of Doxorubicin
OBJECTIVE The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand triggered doxorubicin (DOX) release and whereby the microspheres as well as the drug releasing process can be visualized in vivo using MRI. METHODS AND FINDINGS For this purpose, barium crosslinked alginate microspheres were loaded with temperature sensitive lip...
متن کاملSelective non-covalent triggered release from liposomes.
A zinc(II)-dipicolylamine coordination complex selectively associates with anionic liposomes, including sterically protected PEGylated liposomes, and causes rapid leakage of encapsulated contents.
متن کاملThermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of doxorubicin.
A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale Research Letters
سال: 2012
ISSN: 1556-276X
DOI: 10.1186/1556-276x-7-462